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##  45 results 

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### 2017

Daniele J, Baqri R, Kunes S. [Analysis of axonal trafficking via a novel live-imaging technique reveals distinct hedgehog transport kinetics](/publications/analysis-axonal-trafficking-novel-live-imaging-technique-reveals-distinct). Biol Open. 2017;6(5):714–721. doi:10.1242/bio.024075



 

 

Daniele J, Baqri R, Kunes S. [Analysis of axonal trafficking via a novel live-imaging technique reveals distinct hedgehog transport kinetics](/publications/analysis-axonal-trafficking-novel-live-imaging-technique-reveals-distinct). Biol Open. 2017;6(5):714–721. doi:10.1242/bio.024075



 

 

 

- add\_circle\_outline do\_not\_disturb\_on Abstract
 
The Drosophila melanogaster (Dmel) eye is an ideal model to study development, intracellular signaling, behavior, and neurodegenerative disease. Interestingly, dynamic data are not commonly employed to investigate eye-specific disease models. Using axonal...



 

 

 

Daniele J, Chu T, Kunes S. [A novel proteolytic event controls Hedgehog intracellular sorting and distribution to receptive fields](/publications/novel-proteolytic-event-controls-hedgehog-intracellular-sorting-and). Biol Open. 2017;6(5):540–550. doi:10.1242/bio.024083



 

 

Daniele J, Chu T, Kunes S. [A novel proteolytic event controls Hedgehog intracellular sorting and distribution to receptive fields](/publications/novel-proteolytic-event-controls-hedgehog-intracellular-sorting-and). Biol Open. 2017;6(5):540–550. doi:10.1242/bio.024083



 

 

 

- add\_circle\_outline do\_not\_disturb\_on Abstract
 
The patterning activity of a morphogen depends on secretion and dispersal mechanisms that shape its distribution to the cells of a receptive field. In the case of the protein Hedgehog (Hh), these mechanisms of secretion and transmission remain unclear. In...



 

 

 

 



### 2014

Baqri R, Pietron A, Gokhale R, Turner B, Kaguni L, Shingleton A, Kunes S, Miller K. [Mitochondrial chaperone TRAP1 activates the mitochondrial UPR and extends healthspan in Drosophila.](/publications/mitochondrial-chaperone-trap1-activates-mitochondrial-upr-and-extends) Mech Ageing Dev. 2014;141-142:35–45. doi:10.1016/j.mad.2014.09.002



 

 

Baqri R, Pietron A, Gokhale R, Turner B, Kaguni L, Shingleton A, Kunes S, Miller K. [Mitochondrial chaperone TRAP1 activates the mitochondrial UPR and extends healthspan in Drosophila.](/publications/mitochondrial-chaperone-trap1-activates-mitochondrial-upr-and-extends) Mech Ageing Dev. 2014;141-142:35–45. doi:10.1016/j.mad.2014.09.002



 

 

 

- add\_circle\_outline do\_not\_disturb\_on Abstract
 
The molecular mechanisms influencing healthspan are unclear but mitochondrial function, resistance to oxidative stress and proteostasis are recurring themes. Tumor necrosis factor Receptor Associated Protein 1 (TRAP1), the mitochondrial analog of Hsp75...



 

 

 

 



### 2012

Song E, Bivort B, Dan C, Kunes S. [Determinants of the Drosophila odorant receptor pattern.](/publications/determinants-drosophila-odorant-receptor-pattern-0) Dev Cell. 2012;22(2):363–76. doi:10.1016/j.devcel.2011.12.015



 

 

Song E, Bivort B, Dan C, Kunes S. [Determinants of the Drosophila odorant receptor pattern.](/publications/determinants-drosophila-odorant-receptor-pattern-0) Dev Cell. 2012;22(2):363–76. doi:10.1016/j.devcel.2011.12.015



 

 

 

- add\_circle\_outline do\_not\_disturb\_on Abstract
 
In most olfactory systems studied to date, neurons that express the same odorant receptor (Or) gene are scattered across sensory epithelia, intermingled with neurons that express different Or genes. In Drosophila, olfactory sensilla that express the same...



 

 

 

Dearborn R, Dai Y, Reed B, Karian T, Gray J, Kunes S. [Reph, a regulator of Eph receptor expression in the Drosophila melanogaster optic lobe.](/publications/reph-regulator-eph-receptor-expression-drosophila-melanogaster-optic-lobe-0) PLoS One. 2012;7(5):e37303. doi:10.1371/journal.pone.0037303



 

 

Dearborn R, Dai Y, Reed B, Karian T, Gray J, Kunes S. [Reph, a regulator of Eph receptor expression in the Drosophila melanogaster optic lobe.](/publications/reph-regulator-eph-receptor-expression-drosophila-melanogaster-optic-lobe-0) PLoS One. 2012;7(5):e37303. doi:10.1371/journal.pone.0037303



 

 

 

- add\_circle\_outline do\_not\_disturb\_on Abstract
 
Receptors of the Eph family of tyrosine kinases and their Ephrin ligands are involved in developmental processes as diverse as angiogenesis, axon guidance and cell migration. However, our understanding of the Eph signaling pathway is incomplete, and could...



 

 

 

Dearborn J R.E., Dai, Reed, Gray, Kunes. [Reph, a Regulator of Eph Receptor Expression in the Drosophila melanogaster Optic Lobe](/publications/reph-regulator-eph-receptor-expression-drosophila-melanogaster-optic-lobe). PloS . 2012;in press.



 

 

Dearborn J R.E., Dai, Reed, Gray, Kunes. [Reph, a Regulator of Eph Receptor Expression in the Drosophila melanogaster Optic Lobe](/publications/reph-regulator-eph-receptor-expression-drosophila-melanogaster-optic-lobe). PloS . 2012;in press.



 

 

 

 

Song, Kunes. [Determinants of the Drosophila Odorant Receptor Pattern](/publications/determinants-drosophila-odorant-receptor-pattern). Developmental Cell. 2012;22(2):363–376.



 

 

Song, Kunes. [Determinants of the Drosophila Odorant Receptor Pattern](/publications/determinants-drosophila-odorant-receptor-pattern). Developmental Cell. 2012;22(2):363–376.



 

 

 

 

 



### 2010

Huang H-R, Chen Z, Kunes S, Chang G-D, Maniatis T. [Endocytic pathway is required for Drosophila Toll innate immune signaling.](/publications/endocytic-pathway-required-drosophila-toll-innate-immune-signaling) Proceedings of the National Academy of Sciences of the United States of America. 2010;107(18):8322–7.



 

 

Huang H-R, Chen Z, Kunes S, Chang G-D, Maniatis T. [Endocytic pathway is required for Drosophila Toll innate immune signaling.](/publications/endocytic-pathway-required-drosophila-toll-innate-immune-signaling) Proceedings of the National Academy of Sciences of the United States of America. 2010;107(18):8322–7.



 

 

 

- add\_circle\_outline do\_not\_disturb\_on Abstract
 
The Toll signaling pathway is required for the innate immune response against fungi and Gram-positive bacteria in Drosophila. Here we show that the endosomal proteins Myopic (Mop) and Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) are...





 

 

 

Murakami S, Dan C, Zagaeski B, Maeyama Y, Kunes S, Tabata T. [Optimizing Drosophila olfactory learning with a semi-automated training device.](/publications/optimizing-drosophila-olfactory-learning-semi-automated-training-device) Journal of neuroscience methods. 2010;188(2):195–204.



 

 

Murakami S, Dan C, Zagaeski B, Maeyama Y, Kunes S, Tabata T. [Optimizing Drosophila olfactory learning with a semi-automated training device.](/publications/optimizing-drosophila-olfactory-learning-semi-automated-training-device) Journal of neuroscience methods. 2010;188(2):195–204.



 

 

 

- add\_circle\_outline do\_not\_disturb\_on Abstract
 
Drosophila olfactory aversive conditioning has served as a powerful model system with which to elucidate the molecular and neuronal mechanisms underlying memory formation. In the typical protocol, flies are exposed to a constant odor stream while...





 

 

 

Huang H-R, Chen Z, Kunes S, Chang G-D, Maniatis T. [Endocytic pathway is required for Drosophila Toll innate immune signaling.](/publications/endocytic-pathway-required-drosophila-toll-innate-immune-signaling-0) Proc Natl Acad Sci U S A. 2010;107(18):8322–7. doi:10.1073/pnas.1004031107



 

 

Huang H-R, Chen Z, Kunes S, Chang G-D, Maniatis T. [Endocytic pathway is required for Drosophila Toll innate immune signaling.](/publications/endocytic-pathway-required-drosophila-toll-innate-immune-signaling-0) Proc Natl Acad Sci U S A. 2010;107(18):8322–7. doi:10.1073/pnas.1004031107



 

 

 

- add\_circle\_outline do\_not\_disturb\_on Abstract
 
The Toll signaling pathway is required for the innate immune response against fungi and Gram-positive bacteria in Drosophila. Here we show that the endosomal proteins Myopic (Mop) and Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) are...



 

 

 

Murakami S, Dan C, Zagaeski B, Maeyama Y, Kunes S, Tabata T. [Optimizing Drosophila olfactory learning with a semi-automated training device.](/publications/optimizing-drosophila-olfactory-learning-semi-automated-training-device-0) J Neurosci Methods. 2010;188(2):195–204. doi:10.1016/j.jneumeth.2010.02.007



 

 

Murakami S, Dan C, Zagaeski B, Maeyama Y, Kunes S, Tabata T. [Optimizing Drosophila olfactory learning with a semi-automated training device.](/publications/optimizing-drosophila-olfactory-learning-semi-automated-training-device-0) J Neurosci Methods. 2010;188(2):195–204. doi:10.1016/j.jneumeth.2010.02.007



 

 

 

- add\_circle\_outline do\_not\_disturb\_on Abstract
 
Drosophila olfactory aversive conditioning has served as a powerful model system with which to elucidate the molecular and neuronal mechanisms underlying memory formation. In the typical protocol, flies are exposed to a constant odor stream while...



 

 

 

Tokhunts R, Singh S, Chu T, D’Angelo G, Baubet V, Goetz J, Huang Z, Yuan Z, Ascano M, Zavros Y, et al. [The full-length unprocessed hedgehog protein is an active signaling molecule.](/publications/full-length-unprocessed-hedgehog-protein-active-signaling-molecule) The Journal of biological chemistry. 2010;285(4):2562–8.



 

 

Tokhunts R, Singh S, Chu T, D’Angelo G, Baubet V, Goetz J, Huang Z, Yuan Z, Ascano M, Zavros Y, et al. [The full-length unprocessed hedgehog protein is an active signaling molecule.](/publications/full-length-unprocessed-hedgehog-protein-active-signaling-molecule) The Journal of biological chemistry. 2010;285(4):2562–8.



 

 

 

- add\_circle\_outline do\_not\_disturb\_on Abstract
 
The hedgehog (HH) family of ligands plays an important instructional role in metazoan development. HH proteins are initially produced as approximately 45-kDa full-length proteins, which undergo an intramolecular cleavage to generate an amino-terminal...





 

 

 

 



 

 

 

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